Podcast | GLP-1s, Anhedonia, and the Dopamine Trade-Off with Dr. Robin Berzin

Or, listen on Spotify.

A low dose of tirzepatide, taken purely to move the needle on cholesterol, turned out to move a lot more than that. In this episode, Jeff sits down again with Dr. Robin Berzin, founder of Parsley Health, to go through his bloodwork and an unexpected side effect: a blunting of desire that shows up in his coffee, his cocktails, and his ambition.

• Why losing your appetite for food can also mean losing it for coffee, alcohol, and sex
• What the dopamine and serotonin circuitry are actually doing on a GLP-1
• The line between healthy desire and maladaptive craving, and where these drugs land on it
• Why some people feel liberated when "food noise" disappears, and others feel flattened
• What Jeff's ApoB and LDL numbers say about who these drugs actually help

 This episode is for anyone on a GLP-1 or weighing one, and anyone curious what these drugs are doing beyond the scale.

This episode was made possible by:

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• LMNT: Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase at ⁠drinklmnt.com/commune⁠.
• CocoaVia: Use code COMMUNE2026 for 25% off at CocoaVia.com

About the Commune Podcast

Hosted by Jeff Krasno, the Commune podcast features thoughtful conversations for modern times. Not always comfortable but definitely needed, we explore both humanity and our human-ness. How can we live healthy, purpose-filled lives and be in service of something bigger? Guests include spiritual teachers, poets, scientists, philosophers, and activists for food sustainability, functional medicine, mental and physical health, and collective healing.