Podcast | GLP-1s Gave Me the Ick: A Personal Metabolic Experiment

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Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy.

• What changed in the first two weeks: appetite, weight, and energy
• Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels
• Why alcohol and coffee stopped feeling rewarding
• The emerging link between GLP-1s, dopamine, and the brain's reward circuitry
• The trade-off between appetite control and a sense of vitality or spark

This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines.

This episode was made possible by:

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About the Commune Podcast

Hosted by Jeff Krasno, the Commune podcast features thoughtful conversations for modern times. Not always comfortable but definitely needed, we explore both humanity and our human-ness. How can we live healthy, purpose-filled lives and be in service of something bigger? Guests include spiritual teachers, poets, scientists, philosophers, and activists for food sustainability, functional medicine, mental and physical health, and collective healing.